The NHS health trust which runs four Greater Manchester hospitals could axe up to 800 posts as it struggles to cope with a deficit of £21m.
The cuts will be made by Pennine Acute Trust at North Manchester General, Royal Oldham, Rochdale Infirmary and Fairfield General Hospital in Bury.
Compulsory redundancies are not being ruled out, although the trust said this would be a last resort. A recruitment freeze and review of temporary staff is under way.
Hospitals across England have announced thousands of job losses over the past few weeks as trusts struggle to cope with spiralling debts.
Pressure group Health Emergency claimed the number of NHS job cuts announced in recent weeks had now topped 10,000.
But Andrew Foster, former workforce director at the Department of Health, said the health service would see few “real” redundancies.