Workers fighting against plans to close the Boddingtons Brewery in Manchester are beginning a four-day strike.
Staff are protesting at owner Interbrew's plans to move production from Strangeways, with the loss of a total of 55 jobs.
The industrial action, which is part of a series of strikes, started at 6 am this morning.
The workers also plan to get 'brand protection' for the beer, making a move from its home city difficult. If an application to the EU is successful, it will use its advertising slogans to link the brand with the city.
Interbrew is planning to keep cask ale production in Manchester after the closure, but main production work will move to Lancashire, Scotland and Wales.