Engineering group Cookson is to cut 1,250 jobs worldwide, with the loss of nearly 180 jobs in the UK.
Cookson said it planned to shut its manufacturing plant at Newmilns, Ayrshire over the next 12 months.
The plant makes components, such as ceramic filters, and is particularly exposed to the steel and automotive industries.
The group employs more than 17,000 people in 35 countries.
Other major firms have also announced job cuts as the redundancy toll continues to mount.
Time Warner is to cut about 700 jobs at its online business AOL – 10% of its workforce, mostly in the US; aeroplane manufacturer Boeing said it would be cutting 10,000 jobs this year, about 6% of its total workforce, although it is unclear whether UK workers will be affected; and coffeeshop operator Starbucks has also revealed plans to cut about 6,700 jobs and shut 300 stores, again mostly in the US.
Follow the latest news on UK job cuts with Personnel Today’s redundancy tracker.