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Wellbeing and health promotionOccupational HealthOHW+

Daily capsule for alopecia given NHS green light

by Nic Paton 26 Feb 2024
by Nic Paton 26 Feb 2024 NICE has approved a once-a-day capsule for treatment on the NHS of alopecia areata
Shutterstock
NICE has approved a once-a-day capsule for treatment on the NHS of alopecia areata
Shutterstock

Thousands of people with severe hair loss caused by alopecia areata are to get access to a new one-a-day capsule treatment on the NHS.

The drug ritlecitinib (also known as litfulo and made by Pfizer) has been recommended by the National Institute for Health and Care Excellence (NICE) as an option for treating severe alopecia areata in people aged 12 and over.

The treatment, taken as a daily pill at home, works by reducing the enzymes that cause inflammation and subsequent hair loss at the follicle. It is the first treatment for severe alopecia areata recommended by NICE for use on the NHS.

The recommendation has come after ritlecitinib was initially not recommended for NHS use by NICE’s independent appraisal committee in September last year.

However, following a public consultation and the company providing additional information and an improved discount to its price the treatment, that decision has been reversed and the drug is now recommended as clinically and cost-effective.

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Evidence from clinical trials shows that ritlecitinib is more effective than placebo at improving hair regrowth and that response rates continued to improve for people taking ritlecitinib for up to two years.

Helen Knight, director of medicines evaluation at NICE, said: “Our committee heard how severe alopecia areata can have a significant impact on people’s health and quality of life. I’m delighted that we are now able to recommend this innovative treatment, the first time a medicine for severe alopecia areata has been recommended by NICE for use in the NHS.

“It is especially pleasing that we have been able to recommend ritlecitinib just 16 weeks after it was granted a licence by the Medicines and Healthcare Products Regulatory Authority (MHRA), demonstrating NICE’s commitment to getting the best care to patients fast.”

The recommended dose is a 50mg capsule taken daily.

Alopecia areata is an autoimmune disease, where the body’s immune system attacks the hair follicles causing the hair to fall out. In severe cases, hair is lost from across the body.

Lack of hair on parts of the body other than the scalp, including eyelashes and eyebrows, nasal hair, and hair on the skin leaves people more vulnerable to infections and reduces their ability to regulate their body temperature.

Hair loss in alopecia areata can occur suddenly and may affect people of all ages. The hair follicles are not destroyed but become dormant, making regrowth possible. The extent and duration of hair loss can vary widely from person to person.

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Nic Paton

Nic Paton is consultant editor at Personnel Today. One of the country's foremost workplace health journalists, Nic has written for Personnel Today and Occupational Health & Wellbeing since 2001, and edited the magazine from 2018.

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